Decoy Molecule Could Stymie Chronic Pain

rnaResearchers at the University of Texas at Dallas believe they have created a new weapon in the war against chronic pain. According to researchers, they say they’ve created an RNA-mimicking molecule that can block a series of pain sensations that normally occur after an injury. By studying how this molecule interacts with pain sensations, researchers believe they may be able to develop a new class of drugs that can prevent pain at the outset without increasing a person’s risk of addiction.

“Our results indicate that local treatment with the decoy can prevent pain and inflammation brought about by a tissue injury,” said study lead author Dr. Zachary Campbell.

He believes the findings are very important because chronic pain-related conditions are “the primary reason Americans are on disability.”

“Poorly treated pain causes enormous human suffering,” said Dr. Campbell, “as well as a tremendous burden on medical care systems and our society.”

Cutting In To Opioid Abuse

Opioid addiction and overdoses have increased in recent years as more people turn to pills to help manage their pain. In the right hands with the right dosage, opioids can play an integral role in a pain management plan. However, opioids can be a slippery slope to addiction if they are abused, which is why researchers are looking to develop new medications that are abuse deterrent.

Our current opioids have a major disadvantage in that they interact with areas of our brain that deal with reward and emotion. This can lead to a craving or addiction to the reward stimulus that the drugs provide, but by studying the artificial RNA-molecule, we may be able to develop drugs that stop pain in other areas of the body without crossing the brain-blood barrier.

This artificial molecule works in nociceptors, which are special cells at the injury site that help send pain signals to the brain. After the injury, RNA molecules begin the process of facilitating proteins that signal pain. By mimicking RNA, the decoy molecule can interrupt this process that makes these proteins, and reduce our body’s behavioral response to pain.

“When you have an injury, certain molecules are made rapidly. With this Achilles’ heel in mind, we set out to sabotage the normal series of events that produce pain at the site of an injury,” said. Dr. Campbell. “In essence, we eliminate the potential for a pathological pain state to emerge.”

This is certainly an interesting development, and I hope it opens up new ways to combat chronic pain. We’ll keep an eye out for more information about this protein in the coming years, as it may have big implications for how pain is managed.

Making Pain Patients and Doctors Feel Like Outlaws

painkiller abuse doctorAn opinion piece by Dr. Thomas Cohn

I spent Friday evening with my staff trying to get authorization for medications for one of my patients. The process started on Wednesday when we changed the opioid dosing to a more logical plan based on the needs of the patient. That is when the problem started with the insurance company. We obtained the first authorization for the long-acting medication, then the change for the short-acting medication was refused since the insurance company decided it was too high a dose for a month. We were given a peer review and scheduled a time for the review, but the insurance company physician did not call. We then were finally told on Friday at 3:00 p.m. that the doctor would talk to us and we called immediately.

This was a total sham, the doctor read the insurance company guidelines and said he had no ability to change what was written. Since I have done many reviews as both the reviewer and the one asking for review, the person reviewing can tell the insurance company the rationale for any decision for a patient if medically indicated. It did not seem like anyone at the insurance company cared about the patient.

Villianizing the Patient

For starters, a few patients have very significant medical conditions that may be appropriately treated with opioids. For cancer patients, there is no question that it is within reason to treat with these medications. Some patients also have severe medical conditions that are causing progressive deterioration of the body and likely will lead to death eventually, and opioids also are reasonable. Lastly, some patients have failed every other treatment or surgery and were left with such significant body dysfunction that opioids are the only thing that helps manage pain. These patients are extremely compliant, not abusing their medications, and are being treated by reputable providers, not pill mill doctors. Unfortunately, this patient fell into the class of having a nasty progressively deteriorating neurological condition that has been causing significant pain as well as difficulty with daily activities.

Trying to obtain understanding for the patient who needs medications is supposed to be relatively straightforward. There are guidelines on prescribing to reduce using medications inappropriately, especially in acute settings for starting an opioid regimen. For patients who have legitimate uses for these medications, they are supposed to be able to obtain them if the physician feels it is indicated. Again, this patient appears to have a very significant neurological disorder affecting the whole body, and it is causing significant pain that other treatments will not stop and other medications do not help.

As a pain physician, I was being asked by her other doctors to manage the pain medications. Being board certified in pain, one would think recommendations for medications would have good reasoning as well as being up-to-date with concerns of abuse. If another board certified pain physician saw the recommendations made, I am sure they would agree on the treatment. So when a peer review occurs and the physician says he can do nothing, it is clearly not a well-trained physician and they should not be reviewing such a complex case. The insurance company should fire such doctors from their review panels. Furthermore, it can put a patient in jeopardy since needed medications are not obtainable.

Insurance Problems

The insurance company also had a major fail in patient management. The doors close at 5:00 p.m. on Friday. All the phones start rolling over to automated voice call systems. There is no emergency contact person available to obtain authorizations. There is no contact person for any information so the patient can obtain the necessary treatment. Friday and the weekend comes, and you are out of luck.

The most infuriating aspect of the process is no one seemed to care at the insurance company, the pharmacy benefits company or the patient’s pharmacy. I was totally insulted by the Walgreen’s pharmacist who implied that they could not prescribe because physicians like me were causing the opioid abuse problem and patients like the one receiving the medications were obviously abusers. Statements like that are divisive and show clear ignorance and bias. Legitimate pain patients should not be made victims and neither should their physicians.

The opioid crisis is a problem related to addiction and only minimally related to pain management. In pain practices run by board certified physicians that are providing full service management strategies, opioid abuse is likely less than 5 percent of those patients using medications. When the need is legitimate, pain physicians should be given the ability to make the right recommendations and not need to waste time on approvals versus providing treatment. There are very few specialists in pain care, and providing appropriate medication management by these physicians should be encouraged.

Beyond just prescribing, the insurance companies need to step up and pay for the complex solutions like injections, behavioral health interventions, physical therapy, health clubs, dieticians and other integrative approaches to pain management. The patient and the physician trying to develop appropriate treatment plans should not be stymied but encouraged. The chronic pain patient and board certified pain physicians are not the cause of the opioid crisis. The opioid crisis is really a crisis that started from the lack of treatments for pain. Find the solutions for pain and the addiction crisis will start to crumble. Until we understand pain management, we may continue to have a opioid abuse crisis.

The Gender Disparity of the Opioid Crisis

chronic pain pills womenA recent opinion piece in the Star Tribune shined a light on the problem different genders face in the opioid crisis, particularly the challenges faced by women.

One of the main talking points is that deaths from opioid overdoses have increased much faster for women than for men. Female deaths from opioid overdoses have increased 400 percent in recent years compared to 265 percent for men. Both of these numbers are very problematic, but it helps to show that the opioid crisis is affecting each gender differently.

When opioids affect women, it can oftentimes have a bigger trickle down affect than when it affects men. As the article states, in most American families the woman is the primary caregiver, and the woman’s well-being is often closely tied to the health and future of the children. Opioid abuse by the primary caregiver can often lead to problems down the road for the children, and it increases their likelihood of having their own battles with substance abuse. When opioids negatively affect women, it rarely impacts just one person.

Fixing The Problem

The article went on to suggest some ways to reduce opioid disparity and the larger problem of gender-based health disparities in the United States. Some of the proposed solutions include:

  • Addiction risk education for doctors and patients
  • More education has led to fewer opioid prescriptions and in some places, a downturn in overdose deaths
  • Better emergency room treatment
  • Education campaigns to change dosage standards for women
  • Increased doctor education in states where women disproportionately suffer from conditions like obesity, high blood pressure, diabetes, chronic pain and heart problems
  • Stop cutting insurance coverage for certain programs like Medicaid and Medicare

It’s clear that there’s no one-size-fits-all answer for fixing the opioid crisis and gender-based healthcare disparities throughout the country, but the first step is to help spread awareness that a problem exists. Then we need to put a plan of action in place and stop making the bottom line a higher priority than the health of the patient in our office.

Opioids certainly have a place to help patients when properly assigned and administered, but far too often they are being blindly prescribed and without safety measures in place if abuse begins. The Star Tribune article is a step in the right direction by calling attention to the problem, but now we need doctors, patients and our legislatures to follow through. For the sake of women and families across the country, I hope we can work towards a solution.

How To Be Realistic About New Year’s Resolutions

new years resolutionsIt’s the beginning of a new year,  and we all need to be realistic and open to looking at ways to improve ourselves. It is not an easy proposition, but with a little devotion it can be done. Take sometime now and begin by writing down tangible things you want in the next year, and then begin planning how you will achieve those goals. Look at the different aspects of your life from work to home life, and figure out what would you like to see change.

How To Make These Changes Happen

The first thing about change is to be realistic. Weight loss and exercise are some of the most common areas people want to be change. If you gained 50 pounds over the last five to ten years, it is unlikely that in 3-6 months that you will permanently lose the weight. However, losing a pound a week with a plan that involves changing your food intake, exercise, and having support of others and more knowledge of what has led to weight gain, may lead to success.  

To be successful one also has to make the time for the change to happen. If exercising daily is a goal, sitting for an hour watching TV may have to change. You need to look at your current schedule and see what can be changed to make something happen. Further, do not fight with yourself. If you are not a morning person, do not try to wake up extra early to exercise since it is unlikely to happen. Find a time like after work and make it a priority, and combine it with something you like doing, such as watching TV at the same time or maybe listening to audio books.

Having help to make a change in your life is useful and motivating. Being part of a community with similar goals can help drive you through positive social connections. Sharing the challenge of exercise or weight loss with others who have the same desires can push you forward when you may have doubts. A team of support and friends to share the triumphs can make the grind easier since it is not only about you.

Finding Motivation

One of the hardest things to make a change is having motivation. Everyone has something different that makes one tick. Finding what keeps you going is tough and usually you need multiple reasons. Exercise makes almost everyone feel better overall, but that is often insufficient. For many, without exercise, their pain increases, stress increases, energy levels go down, sleep deteriorates, and for some if they stop, surgery may be the next treatment option. Further, some people are self-motivated while others need to be with others to be consistent and be part of a community or team.

Lastly, change is difficult, and consider a secondary plan if the goals are not being met. Sometimes there are a variety of factors that interfere with meeting a new goal. Do not get stuck with negative thoughts of failure. Change the targets and keep trying to move forward. Look for a different strategy and seek out help to make change. No one is alone in this world and there are numerous resources for help to meet almost any reasonable goal. Think positive and move forward, do not try to change too many aspects of your life at once. Choose just a few things and make it point of achieving them, and then add in new challenges.

Loneliness and Chronic Pain

loneliness painChronic pain is difficult to manage for a variety of reasons, and pain is only part of the problem. Chronic pain disrupts your social life, and it can leave you feeling isolated or with feelings of loneliness. Maintaining a healthy mindset and combating these feelings of isolation are key in treating the whole issue of chronic pain. Today, we share some ways to avoid feeling alone if you’re dealing with a chronic condition.

Preventing Isolation With Chronic Pain

Here are some things you can do if you’re feeling like your chronic pain condition is making it difficult to connect with the outside world:

1. Join A Support Group – The key to avoiding feelings of isolation when battling a chronic pain condition is to remember that you are not alone. At times it may seem like you are alone, but there are so many others dealing with the same condition. Ask your doctor if they know of any support groups for people living with your condition, or perform a simple online search. Odds are a support group is only a couple clicks away!

2. Lean On Close Friends – Not everyone is going to understand what you’re going through, and that’s fine. However, odds are you have a couple friends that are sympathetic and understand what you’re going through. Make plans to connect with these people, even if it’s just once or twice a month for coffee. Pain can sometimes interrupt these plans, but your close friends will understand and adapt, and making plans gives you something to look forward to instead of just dwelling on your pain condition.

3. Exercise – Exercise releases endorphins in your brain that can enhance your mood, and it also gives you a sense of accomplishment. Pain can make exercise difficult, but odds are you can find a few exercises that you can perform without pain getting in the way. Exercise also helps to combat chronic pain, so aside from helping put you in a positive frame of mind, it’s also helping you fight against chronic pain.

4. Talk About Your Emotions – Don’t bottle up your emotions. It’s helpful to talk about your feelings and vent about your frustrations when it comes to chronic pain. If you don’t want to talk to your friends or family about your feelings, bring them up to a doctor, your support group or a therapist. It’s important to remember that these feelings are normal, but hiding them or trying to mask them can actually make them worse. You’ll also feel more connected with others if you open up to them about what you’re going through.

For more tips on combating feelings of loneliness or isolation, reach out to Dr. Cohn and his team today.